Test 400 Injection – Post Injection Pain (Pip) And How To Reduce


Three different testosterone analogs—testosterone cypionate, cypionate enanthate, and cypionate propionate—are combined to create a tri-blend (TEST 400). It is feasible to offer a more continuous, natural testosterone balance by combining these three highly strong testosterone oils, which will smooth the peaks and valleys of serum testosterone associated with each separate treatment. Testosterone waves that are produced by this equilibrium are comparable to the hormone’s circadian rhythm. Frequently, Tri-Blend is given in an MCT Oil Base, which contains Medium Chain Triglycerides linked to dairy, palm kernel oil, and coconut oil to increase the therapeutic effects.

There are numerous mixtures and kinds of testosterone injections. Testosterone Cypionate and Testosterone Enanthate are two of the most popular and widely used Testosterone Esters. They are both made to deliver a long-acting dose of therapeutic Testosterone. Even while these forms of testosterone work well on their own, many hormone clinics use blends of different testosterone to increase the stability of test levels in the bloodstream while undergoing treatment. One of the more popular varieties of combination testosterone injection is tri-blend testosterone.

For males whose bodies are unable to naturally manufacture enough testosterone, the medication Test 400 (Testosterone Tri-Blend) is prescribed. Numerous common male actions, including the growth of the genitalia and the development of muscles and bones, are often attributed to testosterone, which also has a significant impact on how the male body functions. It even aids in fostering healthy sexual development in guys, which is important. The drug class of androgens includes testosterone. We can appreciate the significance of testosterone’s functioning once we are aware of this. The sex hormone testosterone serves a variety of purposes in the body. It is even alleged that it regulates male libido, fat distribution, muscular mass and strength, red blood cell production, bone mass, and sperm creation. A tiny level of testosterone is present in the blood.


When it comes to regulating hormone levels, testosterone injections frequently offer the best value and most control. While not every shot will hurt, the majority of people will occasionally feel some injection pain. Following injections, pain and soreness are perfectly normal and typically not alarming. In one study, 80% of subjects reported experiencing some level of discomfort, which “peaked just after injection, barely reached a mild severity, lasted one to two days, and went. I administered intramuscularly (IM) shots twice a week using 1.5” needles for the first 16 years I was on hormones. Nearly 50% of the time when I performed IM shots, I felt some shooting pain. Although it was seldom severe, the pain occasionally made squats and lunges uncomfortable.

The pain frequency decreased to roughly 1 out of every 5-6 shots after I ultimately converted to weekly subcutaneous (sub-q) injections. The shorter needles used with sub-q resulted in a significant decrease in the frequency of pain. In addition, my pain decreased from moderate to low in intensity. My shooting pain has completely subsided in recent weeks. What took place? I initially began utilizing the Inject-Ease auto-injector (more on that below). I also started putting much of the advice in this post into practice. Hopefully, the information provided may ease your shot discomfort and give you some comfort.

List of factors to reduce post-injection pain:

  • Injection location
  • Gauge, length, and “switching up” of the needle
  • Quantity of injection
  • Technique for injection, including injection rate
  • Manual pressure and massage

INJECTION LOCATION: Testosterone is thoroughly injected into vascular muscle tissue with IM injections. The most popular locations for IM injections are the deltoid (arm), vastus lateralis (thigh), and gluteal muscles (hip/buttocks). Pain is more likely to occur at some injection locations than others. In general, injection locations that have less subcutaneous fat on the body are less uncomfortable. It’s crucial to rotate injection sites! Before injecting again at a particular place, wait a week or two. By doing this, the development of scar tissue and injection site responses are reduced.

GAUGE, LENGTH, AND “SWITCHING UP” OF THE NEEDLE: The patient will experience more discomfort if the needle used for the injection isn’t long enough to reach the muscle mass under the skin. The usual testosterone injection needle gauge ranges from 22 to 25. Although it makes sense that using a smaller gauge needle will lessen injection pain, scientists haven’t agreed on this. Simply tell blunts no! Trans guys are frequently instructed to draw up with one needle, discard it, and then “swap up” to a higher gauge needle for injection. Although it’s not difficult to assume that a needle with a duller tip would hurt more, investigations have not consistently found that this is the case.

QUANTITY OF INJECTIONS: Pain following injection may be influenced by the injection volume. Compared to larger injections given every two weeks, smaller, more frequent injections are likely to cause less pain.

TECHNIQUE FOR INJECTION, INCLUDING INJECTION RATE: When assessing post-injection discomfort, injection technique is another factor to take into account, however, the evidence in this regard is similarly ambiguous. In one study, the Air-lock (AL) injection technique was found to be more efficient than the Z-track (ZT) strategy at reducing pain brought on by IM injection. However, additional research from the 1980s discovered the exact opposite to be true, namely that Z-track is connected to decreased post-injection pain. In order to reduce this effect, “the needle trajectory during penetration is controlled along a linear path from point of contact to an endpoint.” To put it another way, the needle should enter the hole with no detours.

MANUAL PRESSURE AND MASSAGE: The advice you discover online regarding this may or may not apply to your Testosterone injection because there are different injection methods for different drugs. For instance, it is strongly advised against massaging the injection site while administering vaccines intramuscularly (IM), since this could force the medicine into the subcutaneous layer, decreasing its efficiency and perhaps causing irritation. Why would the migration of T. into the subcutaneous layer be harmful given that subcutaneous treatment of testosterone has been shown to be effective? Because muscular tissue does not contain pain receptors, only the subcutaneous layer does. By massaging the injection site, you can move the T. into the subcutaneous layer, which has higher pain thresholds. However, the results of a 2001 study showed that massage was useful in lessening adult patients’ perceptions of discomfort following intramuscular injection delivery.


  • To the injection site, use a cold compress.
  • Inquire with your doctor about topical anesthetic.
  • As the rubbing alcohol dries, wait.
  • Try to keep the muscle as relaxed as you can.
  • Apply force to the skin.
  • Speed up or slow down injection.


Following your shot, you can experience some discomfort and soreness; nevertheless, there are some things to watch out for. Because administering injections is more complicated than administering other prescription drugs, I strongly advise that you learn with a medical expert. Additionally, make sure you only take the hormones prescribed to you at the prescribed dosage and that you acquire them from your doctor.

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