What Does T3 Liothyronine Do?


The thyroid hormone triiodothyronine is produced as liothyronine (T3). The most typical conditions it is used to treat include myxedema coma and hypothyroidism. Liothyronine, a synthetic version of the thyroid hormone L-triiodothyronine, or T3, is used as a thyroid replacement therapy. The condition known as hypothyroidism, in which the thyroid gland produces insufficient thyroid hormone, can be treated with it. The hormone that the thyroid is no longer making is replaced by liothyronine. When treating thyroid cancer, this medicine can also be used in larger doses to decrease thyroid activity.

Treatment for an inactive thyroid involves the administration of liothyronine (hypothyroidism). Thyroid hormone, which is typically produced by the thyroid gland, is replaced or provided in greater amounts. An artificial version of the thyroid hormone is liothyronine.

Low thyroid hormone levels may occur spontaneously, due to thyroid gland damage from radiation, medications, or surgery, or as a result of thyroid gland excision. It keeps you healthy to have enough thyroid hormone. Enough thyroid hormone promotes children’s healthy development and proper learning. Other forms of thyroid issues can also be treated with this drug (such as certain types of goiters, and thyroid cancer). Testing for specific thyroid conditions can also be done using it. If infertility is not a result of low thyroid hormone levels, this drug should not be used to treat it.


Take this medication by mouth once daily, generally with or without a meal, as prescribed by your doctor. To keep your thyroid hormone levels constant, it’s best to take it at the same time each day. Use this medication as often as possible to get the most advantages. Never stop taking it without first consulting your physician. In most cases, thyroid replacement therapy is a lifetime commitment. The dosage is determined by your age, health status, the results of any lab tests, and how you respond to treatment.

Liothyronine absorption may be decreased by specific medicines. Antacids, sucralfate, calcium supplements, iron, bile acid-binding resins (such as cholestyramine, colestipol, and colesevelam), simethicone, sevelamer, sodium polystyrene sulfonate, and products containing aluminum or magnesium are a few examples.

Take any of these medications at least 4 hours before or after liothyronine if you take any of them. Take lanthanum at least two hours before or after liothyronine if you must. Fatigue, aches in the muscles, constipation, dry skin, weight gain, a slow heartbeat, or sensitivity to cold are all signs of low thyroid hormone levels. Within a few days, you might notice an improvement in these symptoms. If your condition worsens or does not improve, let your doctor know.


  • During the first few months after starting this medication, particularly in children, temporary hair loss may occur. If this adverse effect lingers or gets worse, let your doctor or pharmacist know as soon as you can.
  • It is possible to have too much thyroid hormone, notwithstanding the likelihood. If you experience any of the following signs of an overactive thyroid: headache, mental/mood changes (such as irritability, anxiousness), increased perspiration, sensitivity to heat, diarrhea, or menstruation changes, call your doctor immediately once.
  • If you have any really significant side effects from having too much thyroid hormone, such as chest pain, a rapid, pounding heartbeat, swelling ankles or feet, difficulty breathing, or unusual fatigue, seek medical attention immediately away.
  • Rarely does this medication cause an extremely severe allergic reaction. However, get immediate medical attention if you experience any major allergic reaction symptoms, such as a rash, itching, or swelling (particularly of the face, tongue, or neck), extreme dizziness, or difficulty breathing.


Follow the manufacturer’s instructions for Liothyronine strictly, or take your doctor’s recommendations. Never use more, less, or for a longer duration than is recommended. Follow all directions on your prescription label and read any drug guidelines or instruction papers that come with the medication. Follow the medication’s instructions exactly.

Liothyronine dosages are often lower for older folks since they may be more sensitive to its effects. If you’re going from another thyroid medication to liothyronine, cease taking the previous medication before beginning to use liothyronine.

Doses of liothyronine are determined by weight (especially in children and teenagers). If you put on or lose weight, your dosage requirements can alter. You will need to take this medication several days in a row leading up to the test if it is administered as a component of a thyroid suppression test. If you skip any doses during this period, let your doctor know. You will require frequent testing of your thyroid function. Tests can help your doctor identify if you have an illness even if you have no symptoms.

Inform your surgeon that you are currently using this medication if you require surgery. You may need to take a quick break. This medicine may affect how certain medical tests turn out. Inform all medical professionals who care for you that you take liothyronine


Access to L-T3 is crucial for thyroid cancer patients, and L-T4 should not be used in place of L-T3 when L-T3 is advised in order to prepare for radioiodine therapy or diagnostic imaging. L-T4/L-T3 combination therapy is not advised for use in pregnant women, people over the age of 60, or anyone with a known cardiac disease of any age since extra caution is needed to prevent over-replacement. Thyroid extracts from desiccated animals are still not advised for the treatment of hypothyroidism.

A “one-step straight transition” from L-T3 to L-T4 may create a phase of under replacement because of the long half-life of L-T4 and the short half-life of L-T3, especially in people who have previously received L-T3 monotherapy. A better option might be to gradually reduce L-T3 while also introducing L-T4. It is advised to often examine the clinical and biochemical condition of the thyroid until stability is attained. During the transitional period, it’s crucial to understand the pharmacokinetics of L-T3 and L-T4 in order to interpret thyroid function tests.

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