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Liothyronine (Cytomel) is a member of the Thyroid Products medication class. Liothyronine 25mcg is used to treat hypothyroidism, a condition in which the thyroid gland does not produce enough thyroid hormone. Additionally, it is employed in the management of thyroid cancer and the reduction of the size of enlarging thyroid glands (goiter).

Thyroid hormone, which the thyroid gland typically produces, is either replaced or provided in greater amounts. The thyroid hormone can be synthesized as liothyronine. Low thyroid hormone levels can happen spontaneously, as a result of surgery, radiation, medication damage, or other causes. You can maintain good health by getting enough thyroid hormone. Other thyroid issues are also treated with this medication(such as certain types of goiters, and thyroid cancer). Additionally, it can be used to check for particular thyroid conditions. Unless infertility is brought on by low thyroid hormone levels, this medicine shouldn’t be used to cure it. In patients with thyroid cancer, Cytomel is additionally used in conjunction with radioactive iodine therapy and surgery. It is not recommended to use Cytomel to address obesity or weight issues.

Tetraiodothyronine (T4, levothyroxine), triiodothyronine (T3, liothyronine), and/or both are ingredients in natural or synthetic thyroid hormone formulations. Tyrosine is iodinated and coupled to form the thyroid hormones T4 and T3 in the human thyroid gland. Two molecules of diiodotyrosine combine to generate T4, which has four iodine atoms (DIT). One molecule of DIT and one molecule of monoiodotyrosine are coupled to generate T3, which has three iodine atoms (MIT). The thyroid colloid stores both hormones as thyroglobulin.


As directed by your doctor, take this medication by mouth once daily, typically with or without food. It is preferable to take this medication on an empty stomach, at least two hours before or after eating. The prescription label’s instructions should be followed. Take each day at the same time. Never take your prescription more frequently than recommended.

To keep the amount of thyroid hormone constant throughout the day, it is advised to take it at the same time each day. To reap the greatest benefits from this drug, take it frequently Do not stop taking it without first talking to your doctor. The majority of the time, thyroid replacement therapy requires a lifetime commitment. The dosage is determined by your age, health state, the outcomes of any lab tests, and how you respond to treatment.

T3 Liothyronine 25MCG absorption may be decreased by specific medicines. There are several examples, including antacids, sucralfate, calcium supplements, iron, bile acid-binding resins (such as cholestyramine, colestipol, and colesevelam), simethicone, sevelamer, sodium polystyrene sulfonate, and items made of aluminum or magnesium. If you want to take any of these drugs, do so at least 4 hours before or after liothyronine. If you must, take lanthanum at least two hours before or after liothyronine.


Thyroid hormone dosage is based on the indication and must always be customized based on the patient’s response and test results.

“The recommended dose of Cytomel 25mcg (liothyronine sodium) Tablets is one tablet once per day. Liothyronine sodium has a quick cutoff, although its metabolic effects last for a few days after it is stopped.”

For Mild Hypothyroidism: The beginning dose is 25 mcg per day. The daily dose can then be raised by up to 25 mcg every one to two weeks. The typical daily maintenance dose is 25–75 mcg. Some clinicians recommend the use of liothyronine sodium (T3) over levothyroxine sodium (T4) in individuals who may be more vulnerable to the negative side effects of thyroid medication because of its quick onset and disappearance of action.

For Myxedema: 5 mcg per day is advised as a starting dose. Every one to two weeks, this dosage can be raised by 5 to 10 mcg. When the recommended dosage of 25 mcg per day is reached, it is possible to raise it by 5 to 25 mcg every one to two weeks until a positive therapeutic response is attained. 50 to 100 mcg per day is the typical maintenance dose.

Congenital Hypothyroidism: To obtain the appropriate result, a starting dosage of 5 mcg per day is advised, followed by a 5 mcg increase every 3 to 4 days. For maintenance, infants as young as a few months old could only need 20 mcg per day. 50 mcg per day may be needed after a year. Full adult dosage may be required for those over the age of three(under doctors guidance)

Non-toxic Goiter: 5 mcg per day is the suggested starting dosage. Every one to two weeks, this dosage may be increased by 5 to 10 mcg. When 25 mcg per day is reached, the dosage can be raised by 12.5 or 25 mcg every week or two. The typical maintenance dose is 75 mcg per day.

Therapy should be begun at 5 mcg per day in elderly or pediatric patients, and only increased in 5 mcg increments at the advised intervals. When switching a patient from thyroid, L-thyroxine, or thyroglobulin to Cytomel (liothyronine sodium) Tablets, stop the former medicine, start Cytomel at a low dosage, and gradually raise it based on the patient’s response.

Therapy for Thyroid Suppression: When thyroid hormone is administered in amounts greater than those that the gland naturally produces, endogenous hormone production is suppressed. The thyroid suppression test is based on this, and it’s used to help diagnose people who have moderate hyperthyroidism symptoms but whose initial laboratory tests look normal.

Radioactive iodine uptake is measured before and after Cytomel, (liothyronine sodium) Tablets are administered in doses of 75 to 100 mcg/day for 7 days. After treatment, the radioiodine uptake will sharply decline if thyroid function is controlled normally.

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Given that the effects of the exogenous hormone will be additive to those of the endogenous source, Cytomel (liothyronine sodium) Tablets should be used with caution for patients in whom there is a significant suspicion of thyroid gland independence.


If you have signs of thyroid toxicity, such as chest pain, rapid or pounding heartbeats, feeling heated or anxious, or sweating more than usual, stop using liothyronine and contact your doctor.

Also, contact your doctor at once if you have the following symptoms-

  • Alterations in appetite or weight
  • Shallow or feeble breathing
  • A constant sensation of being chilled
  • Feeling dizzy and as though you might pass out
  • Severe headaches, ringing in the ears, lightheadedness, difficulty seeing, and pain behind the eyes
  • Leg discomfort, stiffness, and difficulty moving the legs (in a youngster or adolescent).

And some common side effects are:

  • Breathing issues
  • Increase in appetite
  • Muscular sluggishness
  • Irregular intervals of menstruation
  • Feeling warm
  • Reduce in weight
  • Insomnia


  • Acts more quickly than alternative thyroid hormone replacement medications.
  • Unlike levothyroxine, does not need to be taken 30 minutes before breakfast.
  • Safe during pregnancy
  • Children can use it safely
  • Readily available in a generic form


At each of your routine doctor’s appointments, they must assess how you or your child is progressing. With the use of this information, your doctor will be able to assess how well the medication is working and determine if you should keep taking it. To detect any side effects, blood tests will be required. Liothyronine should not be used to treat obesity or to shed pounds. This medication is inefficient for helping people lose weight and when taken in higher doses, it may have more severe side effects.

If you experience chest pain, a rapid or irregular heartbeat, excessive sweating, trouble breathing, heat intolerance, anxiety, leg cramps, headache, irritability, sleeplessness, tremors, changes in appetite, weight gain or loss, vomiting, diarrhea, fever, changes in menstrual cycles, hives, or skin rash, call your doctor right away. These signs of a drug overdose may be present in your body.

Diabetic people need to follow their doctor’s instructions and monitor their blood or urine sugar levels. If you detect any changes in your sugar levels, consult your doctor right away. If you think you got pregnant while taking this medicine, tell your doctor as soon as you can. While you are pregnant, you might require a higher dosage of liothyronine.


Since Cytomel contains T3 instead of T4 like most other drugs, it is the strongest thyroid treatment available. It can be taken alone or with other thyroid drugs, and it can be compounded in several ways to postpone the bloodstream release of the medication. The most common reasons for Cytomel side effects are either an allergic response to the binders and fillers in the drug or excessive dosage. You may be able to switch drugs to SR T3 to avoid adverse effects if they are brought on by the binders or fillers. Before increasing your dose if you encounter side effects related to your dose, you may need to address underlying nutritional deficiencies.


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